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Updated: Jun 18, 2026

Active Probe Atomic Force Microscopy with Quattro-Parallel Cantilever Arrays for High-Throughput Large-Scale Sample Inspection
Published on: June 13, 2023
Real time reduction of probe-loss using switching gain controller for high speed atomic force microscopy
Pranav Agarwal1, Tathagata De, Murti V Salapaka
1Department of Electrical and Computer Engineering, NanoDynamics Systems Laboratory, University of Minnesota-Twin Cities, Minneapolis, Minnesota 55455, USA.
This study introduces a novel controller to minimize image artifacts caused by probe-loss during tapping mode atomic force microscopy. The method enhances imaging quality by intelligently adjusting controller gain, recovering lost sample features.
Area of Science:
- Atomic Force Microscopy
- Surface Science
- Image Processing
Background:
- Tapping mode atomic force microscopy (AFM) is susceptible to probe-loss artifacts, degrading image quality.
- Regions of probe-loss occur when the AFM tip loses contact with the sample surface.
- Existing methods struggle to effectively mitigate these artifacts without compromising imaging performance.
Purpose of the Study:
- To develop and demonstrate a new controller to reduce probe-loss affected regions in AFM images.
- To improve the reliability and feature recovery in tapping mode AFM imaging.
- To enable higher controller gains for faster imaging without performance degradation.
Main Methods:
- A switching gain proportional-integral-differential (PID) controller was implemented.
- The controller gain is dynamically adjusted using a "reliability index" signal derived from cantilever oscillations.
- This signal identifies probe-loss regions in real-time.
Main Results:
- The switching gain controller significantly reduced probe-loss areas in AFM images.
- Imaging of a calibration sample at high speed (240 microm/s) showed improved quality.
- Imaging of plasmid DNA at 60 microm/s demonstrated recovery of previously lost sample features.
Conclusions:
- The developed switching gain controller effectively minimizes probe-loss artifacts in tapping mode AFM.
- This approach allows for faster imaging speeds by enabling higher controller gains.
- The method enhances the fidelity and completeness of AFM-based surface topography data.
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