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Dynamic position and force measurement for multiple optically trapped particles using a high-speed active pixel

M Towrie1, S W Botchway, A Clark

  • 1Department of Photon Science, Lasers for Science Facility, Rutherford Appleton Laboratory, Science and Technology Facilities Council, Didcot OX11 0QX, United Kingdom. mike.towrie@stfc.ac.uk

The Review of Scientific Instruments
|November 10, 2009
PubMed
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A novel active pixel sensor tracks multiple optically trapped objects with nanometer accuracy. This technology enables precise measurement of dynamic positions and forces for advanced physical and life science applications.

Area of Science:

  • Microscopy and optical physics
  • Instrumentation and sensor technology

Background:

  • Accurate tracking of microscopic objects is crucial for various scientific disciplines.
  • Existing methods may lack the speed or precision required for dynamic multi-object analysis.

Purpose of the Study:

  • To develop and demonstrate a high frame rate active pixel sensor for simultaneous tracking of multiple optically trapped objects.
  • To achieve nanometer-level motion measurement accuracy for micron-scale objects.

Main Methods:

  • Utilized a 520 x 520 pixel sensor with six independent, flexible regions of interest.
  • Implemented a field-programmable gate array (FPGA) for integrated control of the sensor and optical traps.
  • Achieved high-speed data acquisition up to 20 kHz.

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Main Results:

  • Demonstrated simultaneous tracking of up to six optically trapped spheres.
  • Achieved motion measurement accuracy down to the nanometer level.
  • Enabled force measurements at the femtonewton level.

Conclusions:

  • The developed sensor offers unprecedented capabilities for dynamic analysis of multiple micro-objects.
  • This technology is poised to advance research in physical and life sciences requiring precise manipulation and measurement.
  • The integrated system provides a powerful tool for studying interactions at the microscale.