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Updated: Jun 18, 2026
11:25
Targeting Cysteine Thiols for in Vitro Site-specific Glycosylation of Recombinant Proteins
Published on: October 4, 2017
Protein glycosylation in Candida
Héctor M Mora-Montes1, Patricia Ponce-Noyola, Julio C Villagómez-Castro
1Institute of Medical Sciences, University of Aberdeen, UK. h.mora@abdn.ac.uk
Future Microbiology
|November 10, 2009
Summary
Candidiasis poses a severe health threat, prompting research into fungal invasion mechanisms. Understanding Candida glycobiology offers new targets for antifungal therapies against this opportunistic pathogen.
Area of Science:
- Mycology
- Biochemistry
- Pathogenesis
Background:
- Candidiasis is a life-threatening invasive fungal infection with high mortality rates.
- Understanding fungal invasion and host interactions is crucial for developing new antifungal treatments.
- Candida glycobiology is a growing field of interest for identifying therapeutic targets.
Purpose of the Study:
- To explore the role of Candida glycobiology in fungal pathogenesis.
- To identify key enzymes and glycans involved in host cell invasion and virulence.
- To discuss recent findings in the context of Candida albicans pathogenesis.
Main Methods:
- Enzyme identification and characterization (e.g., dolichol phosphate mannose synthase, dolichol phosphate glucose synthase, glycosidases).
- Analysis of mannan synthesis, structure, and recognition.
- Review of studies on N- and O-linked glycans in Candida.
Main Results:
- Enzymes like dolichol phosphate mannose synthase and dolichol phosphate glucose synthase are critical.
- Mannans play a significant role in host recognition and virulence.
- N- and O-linked glycans are implicated in Candida albicans pathogenesis.
Conclusions:
- Candida glycobiology provides essential insights into fungal pathogenesis.
- Targeting enzymes and glycans involved in glycoprotein metabolism is a promising strategy for antifungal drug development.
- Further research into Candida glycobiology can lead to novel therapeutic interventions.
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