Related Experiment Video
Updated: Jun 18, 2026

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
Published on: January 29, 2019
beta1 integrin targeting to enhance radiation therapy
Jin-Min Nam1, Yoonsun Chung, Howard C Hsu
1Life Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, California 94143-1708, USA.
Purpose:
Cell adhesion to extracellular matrix (ECM) proteins is mediated by the integrin family and has been known to modify radiation sensitivity and resistance in several cell types, including cancer cells. In particular, beta1 integrin signaling has been implicated in the progression and metastasis of various cancers and has been shown to facilitate resistance to radiation therapy.
Conclusion:
In this mini-review, we provide a brief overview of integrin targeting in radiation therapy. We specifically focus on the updated findings of beta1 integrin-mediated signaling pathways after exposure to ionising radiation (IR) using in vitro and in vivo experimental models, which could represent promising therapeutic targets for breast cancer.
Related Concept Videos
Intracellular Signaling Affects Focal Adhesions
Some...
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Activation of Integrins
In "outside-in signaling," external factors in the extracellular space bind to exposed ligand binding sites on integrins. This causes the inactive protein to undergo a conformational change to become active. Integrins are often clustered on the cell membrane. Repetitive and regularly spaced ligand binding events provide an effective stimulus.
Tumor Immunotherapy

