Related Experiment Video

Updated: Jun 18, 2026

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

Measles virus: evidence for association with lung cancer

Netta Sion-Vardy1, Irena Lasarov, Bertha Delgado

  • 1Department of Pathology, Soroka University Medical Center, Beer Sheva, Israel. nsv@bgu.ac.il

Experimental Lung Research
|November 10, 2009
PubMed

Insights

Measles virus antigens were found in most non-small cell lung cancer cases. Pirh2 expression, linked to measles virus, correlated with better patient survival, suggesting a potential role in lung cancer progression.

Area of Science:

  • Oncology
  • Virology
  • Molecular Biology

Background:

  • Lung cancer incidence in nonsmokers is rising (10-15%).
  • The role of measles virus in cancer (carcinogenesis) is largely unestablished.
  • Measles virus phosphoprotein may affect Pirh2, a protein overexpressed in lung cancer that degrades p53.

Purpose of the Study:

  • To investigate the association between measles virus antigens, Pirh2, p53, and clinicopathological features in non-small cell lung carcinoma (NSCLC).

Main Methods:

  • Clinicopathological study of 65 newly diagnosed NSCLC patients over 10 years.
  • Immunohistochemical analysis for measles virus antigens, p53, and Pirh2 using avidin-biotin peroxidase complex.

Main Results:

  • Measles virus antigens detected in 54 of 65 (83%) NSCLC cases.
  • Measles virus antigen expression was associated with older patient age and Pirh2 expression.
  • Pirh2 expression was independently associated with improved patient survival.

Conclusions:

  • Measles virus antigens are frequently present in NSCLC.
  • Pirh2 expression, potentially influenced by measles virus, may be a favorable prognostic marker in NSCLC.

More Related Videos

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification10:21

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Published on: September 20, 2024

Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...