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Related Experiment Video

Updated: Jun 18, 2026

Application of a Dual Upper Limb Task-Oriented Robotic System for the Functional Recovery of the Upper Limb in Stroke Patients
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Application of a Dual Upper Limb Task-Oriented Robotic System for the Functional Recovery of the Upper Limb in Stroke Patients

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Comparing unilateral and bilateral upper limb training: the ULTRA-stroke program design.

A Lex E Q van Delden1, C Lieke E Peper, Jaap Harlaar

  • 1Research Institute MOVE, Faculty of Human Movement Sciences, VU University Amsterdam, Van der Boechorststraat 9, 1081 BT Amsterdam, The Netherlands. l.vandelden@fbw.vu.nl

BMC Neurology
|November 10, 2009
PubMed
Summary

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Exoskeleton-assisted training to enhance lower limb motor recovery in subacute stroke: does timing matter? A pilot randomized trial.

Frontiers in stroke·2026

This study investigates if constraint-induced movement therapy (CIMT) and bilateral arm training (BATRAC) improve upper limb function in stroke survivors. It compares these to conventional therapy to understand recovery mechanisms.

Area of Science:

  • Neuroscience
  • Rehabilitation Medicine
  • Clinical Trials

Background:

  • Upper limb paresis affects 80% of stroke survivors, with limited recovery from conventional treatments.
  • Newer therapies like constraint-induced movement therapy (CIMT) and bilateral arm training with rhythmic auditory cueing (BATRAC) show promise for chronic stroke.
  • The ULTRA-stroke program evaluates these interventions in subacute stroke patients.

Purpose of the Study:

  • To assess the effectiveness of modified CIMT and BATRAC compared to conventional treatment in subacute stroke.
  • To explore the relationship between sensori-motor changes and underlying stroke recovery mechanisms.
  • To understand how specific therapies influence neurobiological changes and patient recovery.

Main Methods:

  • A single-blinded randomized clinical trial (RCT) involving 60 first-ever stroke patients.

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Last Updated: Jun 18, 2026

Application of a Dual Upper Limb Task-Oriented Robotic System for the Functional Recovery of the Upper Limb in Stroke Patients
05:28

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Published on: October 11, 2024

Enhancing Upper Limb Function and Motor Skills Post-Stroke Through an Upper Limb Rehabilitation Robot
04:49

Enhancing Upper Limb Function and Motor Skills Post-Stroke Through an Upper Limb Rehabilitation Robot

Published on: September 6, 2024

Cognitive Function and Upper Limb Rehabilitation Training Post-Stroke Using a Digital Occupational Training System
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Cognitive Function and Upper Limb Rehabilitation Training Post-Stroke Using a Digital Occupational Training System

Published on: December 29, 2023

  • Patients stratified by distal arm motor ability and randomized to modified CIMT, modified BATRAC, or dose-matched conventional therapy for 6 weeks.
  • Primary outcome: Action Research Arm test (ARAT) score. Secondary: haptic robot and magneto-encephalography (MEG) measurements.

    • Main Results:

    • Data collection is ongoing; primary and secondary outcomes will be analyzed post-completion.
    • The study aims to provide group-level and patient-specific effectiveness data.
    • Changes in sensori-motor functioning will be correlated with peripheral stiffness, interlimb interactions, and cortical network changes.

    Conclusions:

    • ULTRA-stroke is a 3-year translational research program.
    • It aims to determine the relative effectiveness of CIMT, BATRAC, and conventional therapy.
    • The findings will enhance understanding of post-stroke recovery mechanisms and guide tailored treatment strategies.