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Updated: Jun 18, 2026

Circulating Tumor Cell Lines: an Innovative Tool for Fundamental and Translational Research

Circulating Tumor Cell Lines: an Innovative Tool for Fundamental and Translational Research

Published on: December 25, 2021

Circulating tumor cells and individualized chemotherapy.

Shao-Rong Yu¹, Jia Wei, Xiao-Ping Qian

¹The Cancer Center, The Affiliated Drum Tower Hospital, Medical School of Nanjing University Clinical Cancer Institute of Nanjing University, Jiangsu, P. R. China.

AI Zheng = Aizheng = Chinese Journal of Cancer

|November 10, 2009

Summary

Circulating tumor cells (CTCs) in blood show promise for personalized cancer therapy. Analyzing CTCs enables real-time gene expression profiling for tailored chemotherapy strategies.

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Microfluidics-based High-throughput Circulating Tumor Cell Sorting and Single-cell Sequencing Technology

Microfluidics-based High-throughput Circulating Tumor Cell Sorting and Single-cell Sequencing Technology

Published on: November 14, 2025

Area of Science:

Oncology
Molecular Biology
Medical Diagnostics

Background:

Circulating tumor cells (CTCs) are detected in the blood of cancer patients, particularly those with metastatic disease.
CTC analysis is rapidly advancing, offering significant potential for personalized chemotherapy.
The importance of CTC research is growing due to the feasibility of real-time gene-expression profiling.

Purpose of the Study:

To review current methods for detecting and enriching circulating tumor cells (CTCs).
To summarize the contribution of these CTC methods to the advancement of individualized chemotherapy.

Main Methods:

Review of existing literature on CTC detection techniques.
Review of existing literature on CTC enrichment techniques.
Analysis of the integration of CTC detection and enrichment for clinical applications.

Main Results:

Various methods exist for CTC detection and enrichment.
These methods are crucial for enabling gene-expression profiling of CTCs.
CTC analysis facilitates the development of personalized chemotherapy regimens.

Conclusions:

Circulating tumor cell analysis is a key development in oncology.
CTC detection and enrichment methods are vital for advancing individualized chemotherapy.
Real-time gene-expression profiling using CTCs holds significant promise for cancer treatment.