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Related Experiment Video

Updated: Jun 18, 2026

Psychophysical Tracking Method to Measure Taste Preferences in Children and Adults

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[The old man and the syrup].

H Delacour¹, J-P Le Berre, A Servonnet

¹Fédération de Biologie Clinique, Hôpital d'Instruction des Armées Bégin, 69 Avenue de Paris, 94163 Saint-Mandé cedex, France.

Pathologie-Biologie

|November 10, 2009

Summary

This summary is machine-generated.

Glycyrrhizin, found in liquorice, can cause severe hypokalemia (low potassium) with prolonged consumption. This case highlights the importance of considering liquorice-induced intoxication in patients with unexplained low potassium levels.

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Area of Science:

Endocrinology
Toxicology
Internal Medicine

Background:

Glycyrrhizin, a component of liquorice root, is known to possess mineralocorticoid activity.
Chronic exposure can lead to pseudoaldosteronism, characterized by sodium retention and potassium excretion.

Observation:

A case of severe hypokalemia is presented in a patient with a history of long-term consumption of a syrup containing liquorice.
The patient presented with symptoms consistent with significant electrolyte imbalance.

Findings:

The severe hypokalemia was directly attributed to intoxication by glycyrrhizin from the liquorice syrup.
The physiopathological mechanism involves glycyrrhizin's inhibition of 11-beta-hydroxysteroid dehydrogenase type 2, leading to cortisol's mineralocorticoid receptor activation.

Implications:

This case underscores the potential for common herbal products to cause serious iatrogenic toxicity.
Clinicians should consider glycyrrhizin exposure in the differential diagnosis of hypokalemia, especially with a history of liquorice consumption.
Awareness of liquorice-induced pseudoaldosteronism is crucial for timely diagnosis and management.