Fabrication of cellular polycaprolactone films for cell culture
Related Experiment Video
Updated: Jun 18, 2026
Thin Film Composite Silicon Elastomers for Cell Culture and Skin Applications: Manufacturing and Characterization
Published on: July 3, 2018
Bo Wang1, Zhengwei Mao, Xinan Meng
1MOE of Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, PR China.
Abstract:
Hierarchical cellular structures consisting of multilayers of ordered pores were created on a poly-epsilon-caprolactone (PCL) film by introducing a colloidal crystal mask/template in thermomechanical lithography. The surface characteristics were measured by scanning electron microscopy, atomic force microscopy, water contact angle and analyzed by Fourier Transform (FT). The resultant PCL films present a metastable superhydrophobicity. Their water contact angles were initially 150 degrees and then declined with time eventually to 115-120 degrees . In vitro culture of human fibroblasts found that the cells could spread on the cellular PCL surface as normal, but showed higher viability compared with the control cells on a flat substrate.
