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Updated: Jun 18, 2026

Anaerobic Protein Purification and Kinetic Analysis via Oxygen Electrode for Studying DesB Dioxygenase Activity and Inhibition
Published on: October 3, 2018
The oxygen-binding vs. oxygen-consuming paradigm in biocatalysis: structural biology and biomolecular simulation
Riccardo Baron1, J Andrew McCammon, Andrea Mattevi
1Department of Chemistry & Biochemistry, University of California at San Diego, La Jolla, CA 92093-0365, USA.
Abstract:
Oxygen biocatalysis and regulation is crucial to a variety of biochemical processes in nature. Oxygen-binding proteins cover only a limited part of oxygen biocatalysis, which involves numerous examples of oxygen-consuming biocatalysts with low oxygen affinities. The integration of experiments with powerful biomolecular simulation opens appealing possibilities to investigate crucial questions on the fascinating relationship between enzyme dynamics and oxygen biocatalysis in new protein structures.
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