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Identification of Dopamine D1-Alpha Receptor Within Rodent Nucleus Accumbens by an Innovative RNA In Situ Detection Technology
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Variation in DRD2 dopamine gene predicts Extraverted personality.

Luke D Smillie1, Andrew J Cooper, Petroula Proitsi

  • 1Goldsmiths, University of London, UK. l.smillie@gold.ac.uk

Neuroscience Letters
|November 10, 2009
PubMed
Summary

This study links the DRD2 TaqIA/ANKK1 gene variant to higher Extraversion scores in university students. This finding supports the role of dopaminergic genes in the genetic basis of personality traits.

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Area of Science:

  • Behavioral genetics
  • Neuroscience
  • Psychology

Background:

  • Extraversion heritability is estimated at 40-60%.
  • Dopaminergic function is theoretically linked to Extraversion.
  • Molecular genetic studies on Extraversion have yielded mixed results.

Purpose of the Study:

  • To investigate the association between Extraversion and the DRD2 TaqIA/ANKK1 polymorphism.
  • To explore the genetic underpinnings of personality variation.

Main Methods:

  • Genotyping of the DRD2 TaqIA/ANKK1 polymorphism in 224 university students.
  • Statistical analysis to determine the relationship between the polymorphism and Extraversion scores.
  • Bootstrap analysis to confirm the robustness of findings.

Main Results:

  • Individuals with at least one A1 allele of the DRD2 TaqIA/ANKK1 polymorphism showed significantly higher Extraversion.
  • Bootstrap analysis validated the statistical significance of this association.

Conclusions:

  • The DRD2 TaqIA/ANKK1 polymorphism is associated with higher Extraversion.
  • This finding contributes to understanding the molecular genetic basis of personality.
  • Methodological considerations may explain previous inconsistent results.