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Updated: Jun 18, 2026

Human iPSC-Derived Cardiomyocyte Networks on Multiwell Micro-electrode Arrays for Recurrent Action Potential Recordings
Published on: July 15, 2019
An interactive graphical user interface for comprehensive analysis of human and swine cardiac monophasic action
Maneesh Shrivastav1, Paul A Iaizzo
1Medtronic Neuromodulation, Minneapolis, Minnesota 55432, USA. maneesh@ieee.org
Abstract:
This research describes a novel monophasic action potential (MAP) annotation algorithm coupled with an interactive graphical user interface (GUI). This algorithm incorporates a number of features to reduce error. Additionally, the GUI has several convenient features to view and manipulate the annotation visually. We analyzed data from swine and human hearts in normal sinus rhythm, during myocardial ischemia, and while eliciting high rates. Validation results indicate correlation >90% between human and computer measurements. This analysis system has several clinical applications in electrophysiological interventions, pharmacodynamic therapies, ischemia detection, and/or in assessment of the time course of electrical activation.
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