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Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...

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Updated: Jun 18, 2026

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor
06:32

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor

Published on: May 2, 2025

Platelet function analysis: a comparison of methods.

Andrew Morris, Bernadette Aliprandi-Costa, David Brieger

    International Journal of Cardiology
    |November 10, 2009
    PubMed
    Summary
    This summary is machine-generated.

    Point-of-care testing for clopidogrel response shows variability. Current devices require further validation before routine clinical use in guiding anti-platelet therapy for patients undergoing PCI.

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    Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

    Published on: May 23, 2025

    Area of Science:

    • Cardiology
    • Pharmacology
    • Biomedical Engineering

    Background:

    • Clopidogrel response varies significantly among patients, with 5-44% exhibiting residual platelet reactivity (RPR).
    • Identifying poor responders is crucial for preventing adverse cardiovascular outcomes, particularly in patients undergoing percutaneous coronary intervention (PCI).
    • Point-of-care (POC) devices aim to facilitate rapid assessment of anti-platelet drug efficacy.

    Purpose of the Study:

    • To evaluate the diagnostic accuracy of the Accumetrics VerifyNow device for assessing clopidogrel responsiveness.
    • To compare the VerifyNow device against a gold-standard flow-cytometric assay (VASP-P) in patients undergoing elective PCI.

    Main Methods:

    • Sensitivity and specificity of the VerifyNow device were assessed.
    • Comparison was made against flow-cytometric analysis of VAsodilator-Stimulated Phosphoprotein (VASP) phosphorylation.
    • The study population comprised patients undergoing elective percutaneous coronary intervention (PCI).

    Main Results:

    • The study assessed the sensitivity and specificity of the VerifyNow POC device.
    • Comparison was performed against the VASP-P assay, a more specific measure of platelet inhibition.
    • Results indicated a need for further investigation into the device's clinical utility.

    Conclusions:

    • Current point-of-care devices for measuring clopidogrel responsiveness require further validation.
    • Larger replication studies are needed to establish standardized guidelines for routine clinical use.
    • Widespread adoption of POC testing for anti-platelet therapy guidance is not yet recommended.