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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...

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Updated: Jun 18, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Chronic radiation enteritis.

V S Theis1, R Sripadam, V Ramani

  • 1University Hospital Aintree, Digestive Diseases Unit Longmoor lane Liverpool L9 7AL, UK. vanessa.theis@aintree.nhs.uk

Clinical Oncology (Royal College of Radiologists (Great Britain))
|November 10, 2009
PubMed
Summary
This summary is machine-generated.

Chronic radiation enteritis, a growing concern in cancer survivors, presents diverse gastrointestinal symptoms. This review highlights limited evidence for treatments but emphasizes a structured approach to investigation and management.

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Area of Science:

  • Gastroenterology
  • Oncology
  • Radiation Oncology

Background:

  • Chronic radiation enteritis incidence is rising due to improved cancer therapy survival rates.
  • Up to 20% of patients receiving pelvic radiotherapy may develop this condition, potentially underestimated.
  • Risk factors include low BMI, prior surgery, comorbidities, and radiotherapy specifics.

Purpose of the Study:

  • To review the causes, investigation, treatment, and prevention of chronic radiation enteritis.
  • To highlight the multifactorial nature of symptoms and the need for a structured diagnostic approach.
  • To assess the current evidence base for therapeutic and preventative strategies.

Main Methods:

  • Comprehensive review of published studies on radiation enteritis.
  • Analysis of search terms including 'radiation enteritis,' 'investigation,' 'treatment,' and 'prevention.'

Main Results:

  • Clinical manifestations are varied, affecting any part of the gastrointestinal tract.
  • Evidence for current therapies (nutrition, anti-diarrheals, anti-inflammatories, etc.) is limited.
  • Preventative strategies, including tissue-sparing radiotherapy, are also reviewed.

Conclusions:

  • The evidence base for managing chronic radiation enteritis remains limited.
  • A structured approach to investigating gastrointestinal symptoms post-radiotherapy is crucial for targeted treatment.
  • Enhanced collaboration between oncologists and gastroenterologists is vital for improving patient management and research.