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Related Concept Videos

Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...

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Related Experiment Video

Updated: Jun 18, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Joint extraintestinal manifestations in ulcerative colitis.

A E Dorofeyev1, I V Vasilenko, O A Rassokhina

  • 1National Medical University, Donetsk, Ukraine. dorofeyev@med.finfort.com

Digestive Diseases (Basel, Switzerland)
|November 10, 2009
PubMed
Summary

Joint extraintestinal manifestations (EIM) are common in ulcerative colitis (UC). This study links joint EIM in UC patients to specific gut bacteria and inflammatory cytokine profiles, impacting disease course.

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Area of Science:

  • Gastroenterology
  • Immunology
  • Microbiology

Background:

  • Extraintestinal manifestations (EIM) frequently affect ulcerative colitis (UC) patients, negatively impacting disease course and quality of life.
  • Joint EIM, including arthritis and arthralgia, are significant complications in UC management.

Purpose of the Study:

  • To investigate the clinical and laboratory characteristics of UC patients experiencing joint EIM.
  • To explore the association between joint EIM, gut microbiota composition, mucosal barrier integrity, and cytokine profiles in UC.

Main Methods:

  • Analysis of clinical data from 319 UC patients, categorizing disease extent (distal, left-sided, pancolitis).
  • Assessment of joint EIM prevalence, focusing on arthritis and arthralgia.
  • Investigation of colon microbiocenosis, mucosal barrier function (lectin staining), and plasma cytokine levels (IL-1, TNF, IL-10).

Main Results:

  • Joint EIM occurred in 29.8% of UC patients, correlating with extensive colitis (left-sided and pancolitis).
  • Arthralgia was more common in distal UC, while arthritis was linked to extensive forms.
  • UC patients with joint EIM showed dysbiosis, increased facultative flora (Staphylococcus, Klebsiella, Proteus), altered mucus receptor maturity, and a pro-inflammatory cytokine profile (elevated IL-1, TNF; decreased IL-10).

Conclusions:

  • Joint EIM in UC is associated with specific gut microbial alterations and a distinct inflammatory cytokine signature.
  • These findings highlight the complex interplay between gut dysbiosis, mucosal changes, and systemic inflammation in UC-related joint manifestations.