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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:

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Related Experiment Video

Updated: Jun 18, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Joint involvement associated with inflammatory bowel disease.

M De Vos1

  • 1Ghent University, Ghent, Belgium. martine.devos@uzgent.be

Digestive Diseases (Basel, Switzerland)
|November 10, 2009
PubMed
Summary
This summary is machine-generated.

Inflammatory bowel disease (IBD) and spondyloarthritis (SpA) share gut-joint inflammation pathways, with anti-TNF therapies showing efficacy but etanercept posing risks. Genetic factors and altered immune responses link these immune-mediated inflammatory diseases.

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Published on: October 14, 2025

Area of Science:

  • Immunology
  • Gastroenterology
  • Rheumatology

Background:

  • Joint involvement in inflammatory bowel disease (IBD) is classified as spondyloarthritis (SpA), encompassing peripheral arthritis and axial arthropathy.
  • While NSAIDs offer short-term relief for arthritis, long-term use is discouraged due to safety concerns, with salazopyrine effective for peripheral arthritis.

Purpose of the Study:

  • To elucidate the pathogenesis of gut-joint iteropathy linking IBD and SpA.
  • To identify common pathways and genetic predispositions contributing to both conditions.

Main Methods:

  • Review of human and animal evidence for gut-joint inflammation links.
  • Transcriptome analysis of mucosal biopsies to identify differentially expressed genes.
  • Genotyping of ankylosing spondylitis (AS) patients to explore shared genetic determinants with IBD.

Main Results:

  • Anti-TNF therapies like infliximab and adalimumab are effective for SpA arthritis, but etanercept is not recommended due to increased risk of intestinal relapse.
  • Transcriptome analysis revealed 95 differentially expressed genes in both Crohn's disease (CD) and SpA, suggesting common pathogenic pathways.
  • Genetic studies indicate overlap in predisposition between CD and AS, notably involving IL-23R polymorphisms and other CD-susceptibility loci.

Conclusions:

  • Clinical, genetic, immunological, and therapeutic evidence strongly support a link between gut and joint inflammation in IBD and SpA.
  • Tumor necrosis factor (TNF) plays a crucial role, with mesenchymal cells potentially being primary targets.
  • Genetic susceptibility is essential, highlighting shared genetic factors between these immune-mediated inflammatory diseases.