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Updated: Jun 18, 2026

In Vivo Vascular Permeability Detection in Mouse Submandibular Gland
Published on: August 4, 2022
The structure of tight junctions in mouse submandibular gland
Kenichiro Kikuchi1, Jitesh Kawedia, Anil G Menon
1Department of Histology, Nippon Dental University, Tokyo, Japan.
Abstract:
Salivary gland cells are joined by junctional complexes consisting of a tight junction (TJ), zonula adherens and one or more desmosomes. TJs regulate paracellular permeability, maintain separate apical and basolateral membrane domains, and serve as signaling centers. We examined TJs of mouse submandibular glands (SMG) in thin sections and freeze-fracture replicas. TJs between acinar cells and between intercalated duct cells had 2-6 parallel strands on the protoplasmic fracture face, with occasional branches, interconnections and free ends, and corresponding grooves on the extracellular face. Granular duct cell TJs had 2-30 strands, a depth of
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