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Antigen Presenting Cells

Antigen Presenting Cells

The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...

Allergic Reactions

Allergic Reactions

Antigens Involved in Adaptive Immunity

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.

Antibody Structure

Antibody Structure

Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...

Antigen Processing Pathways

Antigen Processing Pathways

MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...

Cell-mediated Immune Responses

Cell-mediated Immune Responses

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Updated: Jun 18, 2026

Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation

Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation

Published on: July 23, 2012

[Antigen presenting cells in allergy].

Mitsuyoshi Utsugi¹

¹Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine

|November 11, 2009

Summary

This summary is machine-generated.

Antigen-presenting cells (APCs), primarily dendritic cells (DCs), drive allergic immune responses. Modulating DC function offers new therapeutic strategies for allergic diseases by redirecting T cell responses or inducing tolerance.

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Area of Science:

Immunology
Allergy Research

Context:

Allergic responses involve complex immune cascades and Th2 cytokine dysregulation.
Antigen-presenting cells (APCs), particularly dendritic cells (DCs), are crucial in initiating T cell responses and immune tolerance.

Purpose:

This review examines the role of APCs in allergic reactions.
It explores novel therapeutic strategies for allergic diseases targeting DC subsets.

Summary:

APCs, including DCs, provide essential signals for T cell activation, polarization, and tolerance induction.
The review highlights how manipulating DC subsets can alter T cell polarization or promote tolerance for treating allergies.

Impact:

Understanding APCs' contribution to allergies can lead to targeted immunotherapies.
New treatments may focus on reprogramming DCs to manage or cure allergic conditions.