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Updated: Jun 18, 2026

Applying an Inducible Expression System to Study Interference of Bacterial Virulence Factors with Intracellular Signaling
Published on: June 25, 2015
Communication between microorganisms as a basis for production of virulence factors
Eugenia Gospodarek1, Tomasz Bogiel, Patrycja Zalas-Wiecek
1Department of Microbiology, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, Poland. gospodareke@cm.umk.pl
Abstract:
Quorum sensing (QS), or cell-to-cell communication in bacteria, is achieved through the production and subsequent response to the accumulation of extracellular signal molecules called autoinductors. The main role of QS is regulation of production of virulence factors in bacteria. Bacterial pathogenicity is often manifested by the expression of various cell-associated and secreted virulence factors, such as exoenzymes, toxins and biofilm. In bacteria, the expression of virulence factors is controlled coordinately by the global regulatory QS systems, which includes the AI-1/LuxIR-, AI-2/LuxS-, AI-3/QsC-, AIP/Agr-based systems. The regulation of production of virulence factors is extremely complex and many components influence it.
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