Related Experiment Video
Updated: Jun 18, 2026
Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
Published on: January 12, 2022
Comparison between stereo angiographic findings and histopathologic findings in endotoxin-induced uveitis
Hiroaki Miyashita1, Shigeki Tagawa, Hisashi Takeda
1Department of Ophthalmology and Visual Science, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan. hiro miyashita@hotmail.com
Purpose:
To carry out a three-dimensional analysis of uveitis using stereo angiography.
Materials And Methods:
Endotoxin-induced uveitis was induced by injecting lipopolysaccharide into the rat footpad, and the findings of stereo angiography with a scanning laser ophthalmoscope were compared to histopathologic results.
Results:
On day 2, multiple hyperfluorescent spots were observed by indocyanine green stereo angiography, which appeared to be in the superficial layer of the retina. Histopathologic findings showed infiltration of leukocytes into the corresponding area, which was the retinal nerve fiber layer.
Conclusions:
Stereo angiography was considered useful for three-dimensional analysis of uveitis lesions in the retina and choroid.
