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Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis

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COX-2 expression in uterine carcinosarcoma.

Joseph Menczer¹, Letizia Schreiber, Oleg Sukmanov

¹Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, E. Wolfson Medical Center, Holon, Israel. joseph12@internet-zahav.net

Acta Obstetricia Et Gynecologica Scandinavica

|November 11, 2009

Summary

Cyclooxygenase-2 (COX-2) is frequently expressed in uterine carcinosarcoma

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Area of Science:

Gynecologic Pathology
Oncology
Molecular Pathology

Background:

Uterine carcinosarcoma is an aggressive malignancy with biphasic differentiation.
Cyclooxygenase-2 (COX-2) is implicated in various cancers, but its role in uterine carcinosarcoma is not fully understood.

Purpose of the Study:

To evaluate cyclooxygenase-2 (COX-2) expression in both carcinomatous and sarcomatous components of uterine carcinosarcoma.
To determine if COX-2 expression correlates with clinicopathological prognostic factors and patient survival.

Main Methods:

Retrospective analysis of 27 uterine carcinosarcoma specimens.
Immunohistochemistry was used to assess COX-2 expression in paraffin-embedded tissues.
Pathologists blinded to clinical data evaluated staining intensity and percentage of positive cells.

Main Results:

COX-2 expression was detected in 74% of the carcinomatous component, with 48.2% showing high staining scores.
COX-2 staining parameters were significantly lower in the sarcomatous component.
No significant association was found between COX-2 expression and stage, grade, myometrial invasion, lymphovascular involvement, or survival.

Conclusions:

COX-2 is expressed in a substantial proportion of uterine carcinosarcoma.
Despite its expression, COX-2 does not appear to be a significant prognostic marker or correlate with survival in this patient cohort.