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Chromosome Preparation From Cultured Cells
Published on: January 28, 2014
Novel complex translocation involving 5 different chromosomes in a chronic myeloid leukemia with Philadelphia
Walid Al Achkar1, Abdulsamad Wafa, Hasmik Mkrtchyan
1Molecular Biology and Biotechnology Department, Human Genetics Div,, Atomic Energy Commission of Syria, P,O, Box 6091, Damascus, Syria. scientific@aec.org.sy.
Background:
The well-known typical fusion gene BCR/ABL can be observed in connection with a complex translocation event in only 2-10% of cases with chronic myeloid leukemia (CML). As currently most CML cases are treated with Imatinib, variant rearrangements have in general no specific prognostic significance, though the emergence of therapy resistance remains to be studied.
Results:
Here we report an exceptional CML case with complex chromosomal aberrations not observed before, involving a 5 chromosome translocation implying chromosomal regions such as 1q42, 4p14 and 5q31 besides 9q34 and 22q11.2.
Conclusion:
The reported rearrangement developed most probably in one initial step and had no influence on a good response during Imatinib treatment.
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