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Updated: Jun 18, 2026
16:57
MALDI Imaging Mass Spectrometry of Neuropeptides in Parkinson's Disease
Published on: February 14, 2012
[Parkinsonism due to the medication].
Maartje Louter1, Selma C Tromp
1St Antonius Ziekenhuis, Afd. Neurologie, locatie Nieuwegein, The Netherlands.
Nederlands Tijdschrift Voor Geneeskunde
|November 11, 2009
Summary
Drug-induced parkinsonism, a disorder mimicking Parkinson disease, can be caused by medications like sodium valproate and cinnarizine. Discontinuing the offending drug can resolve these parkinsonian symptoms.
Area of Science:
- Neurology
- Pharmacology
Background:
- Parkinsonism presents with tremor, rigidity, bradykinesia, and postural instability.
- Idiopathic Parkinson disease is the most frequent cause, but drug-induced parkinsonism is also common.
Observation:
- Certain medications can induce parkinsonian symptoms.
- Patients with drug-induced parkinsonism are sometimes incorrectly treated with dopaminergic drugs.
Findings:
- Two cases of drug-induced parkinsonism are presented, one caused by sodium valproate and the other by cinnarizine.
- Parkinsonian symptoms in both patients resolved after medication withdrawal.
Implications:
- Accurate diagnosis of drug-induced parkinsonism is crucial to avoid inappropriate treatment.
- Identifying and stopping causative drugs is an effective management strategy for drug-induced parkinsonism.
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