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Updated: Jun 18, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Bioactive jatrophane diterpenes from Euphorbia guyoniana
Mohamed-Elamir F Hegazy1, Abou El-Hamd H Mohamed, Nobuwa Aoki
1Chemistry of Medicinal Plants Department, National Research Center, Dokki, Cairo, Egypt.
Abstract:
Chromatographic investigation of the methylenechloride/methanol extract of the aerial parts of Euphorbia guyoniana afforded two jatrophane diterpenes, designated guyonianins E and F, in addition to a known jatrophane diterpene. The structures of the compounds were determined by comprehensive NMR analyses, including DEPT, COSY, HMQC, HMBC, NOESY and HRMS. These compounds exhibited cytotoxicity against human embryonic kidney 293 (HEK293) cells with IC(50) values of 35-100 microM.
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