Related Experiment Video
Updated: Jun 18, 2026

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
Published on: May 22, 2014
The soluble pattern recognition receptor pentraxin-3 in innate immunity, inflammation and fertility
Cecilia Garlanda1, Virginia Maina, Alessia Cotena
1Istituto Clinico Humanitas IRCCS, Rozzano, Italy. cecilia.garlanda@humanitas.it
Abstract:
The innate immune system consists of a cellular and a humoral arm. Components of humoral immunity include diverse molecular families, which represent functional ancestors of antibodies. They play key roles as effectors and modulators of innate resistance and inflammation. The long pentraxin PTX3 represents a prototype humoral effector molecule. Gene targeting of this evolutionarily conserved long pentraxin has unequivocally defined its role at the crossroads of innate immunity, inflammation, matrix deposition and female fertility. Here, we will review the studies on PTX3, which emphasize its role as a multifunctional soluble pattern recognition receptor acting as a non-redundant component of the humoral arm of innate immunity involved in fine-tuning inflammation, matrix deposition, angiogenesis and, in particular, in female fertility.
Related Concept Videos
Acute Inflammation I: Inflammatory Response
Selectins
Regulation of the Unfolded Protein Response
Inflammatory Bowel Disease III: Crohn's Disease
The Extrinsic Apoptotic Pathway
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...

