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Updated: Jun 18, 2026
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In Vitro Thrombosis Test for Ventricular Assist Devices
Published on: March 21, 2025
Reference intervals and method optimization for variables reflecting hypocoagulatory and hypercoagulatory states in
Natali Bauer1, Oya Eralp, Andreas Moritz
1Department of Veterinary Clinical Sciences, Clinical Pathophysiology and Clinical Pathology, Justus-Liebig University Giessen, Giessen, Germany. Natali.Bauer@vetmed.uni-giessen.de
Summary
This study establishes crucial reference intervals for canine coagulation tests using the STA Compact analyzer. These validated ranges aid in diagnosing bleeding disorders in dogs, ensuring accurate veterinary care.
Area of Science:
- Veterinary Hematology
- Clinical Pathology
- Canine Coagulation Diagnostics
Background:
- Limited reference intervals exist for canine coagulation parameters on the STA Compact analyzer.
- Accurate diagnostic ranges are essential for effective veterinary hemostasis assessment.
Purpose of the Study:
- To validate coagulation assays on the STA Compact analyzer for canine specimens.
- To establish 95% reference intervals for key coagulation parameters in healthy dogs.
Main Methods:
- Assessed coagulation parameters in 56 healthy dogs using the STA Compact analyzer.
- Developed canine-specific standard curves for protein C, protein S, and factor VIII.
- Evaluated the impact of hemolytic and lipemic plasma on test results.
Main Results:
- Established 95% reference intervals for prothrombin time, APTT, thrombin time, fibrinogen, antithrombin, D-dimer, anti-factor Xa, and APC ratio.
- Determined canine-specific intervals for protein C, protein S, and factor VIII using a canine plasma curve.
- Identified assay interferences in hemolytic and lipemic canine plasma samples.
Conclusions:
- The study provides essential reference intervals for canine coagulation testing on the STA Compact analyzer.
- Modifications are needed for human-calibrated assays (protein C, S, factor VIII, plasminogen) in canine diagnostics.
- Validated ranges improve the accuracy of diagnosing and managing hemostatic disorders in dogs.
