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Updated: Jun 18, 2026
A Three-dimensional Thymic Culture System to Generate Murine Induced Pluripotent Stem Cell-derived Tumor Antigen-specific Thymic Emigrants
Published on: August 9, 2019
Type B3 thymic epithelial tumor in an adolescent detected by immunohistochemical staining for CD5, CD99, and KIT
Naoyuki Yoshino1, Hirotoshi Kubokura, Shigeo Yamauchi
1Department of Surgery, Division of Thoracic Surgery, Nippon Medical School, Tokyo, Japan.
Abstract:
A 16-year-old male patient was admitted to the hospital for a medical workup to examine an anterior mediastinal tumor in April 2000. A tumor excision and a right lower lung lobe nodule resection were performed in June 2000. The tumor tissue showed a cobblestone-like proliferation of atypical cells containing a discrete nucleolus that were aligned in an epithelial fashion against mainly lymphocytic inflammatory cells in the background; also shown were undifferentiated tumor cells with epithelioid characteristics. Immunohistochemical staining for CD5, CD99, and KIT (CD117) revealed that the tumor cells were CD5-negative and that some of the lymphocytes infiltrating the tumor tissue stained positive for CD99 and negative for KIT. The lesion was therefore diagnosed to be a type B3 thymic epithelial tumor.
