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Published on: August 5, 2010
Intravesical oxybutynin in the pediatric neurogenic bladder
1Division of Urology, Red Cross Children's Hospital, University of Cape Town, Rondebosch 7701, Cape Town, South Africa. j.lazarus@uct.ac.za
Abstract:
Pediatric neuropathic bladder dysfunction can cause irreversible renal damage and urinary incontinence. Etiologically, it is usually the consequence of a congenital neural tube defect. The majority of affected children can be successfully managed with the standard medical treatment of clean intermittent catheterization and anticholinergic (typically oxybutynin) medication. A subset of patients experience severe side effects or insufficient suppression of detrusor overactivity on oral oxybutynin. Intravesical instillations offer an effective alternative; this Review considers their indications, administration, safety and efficacy.
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