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Related Concept Videos

Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers01:26

Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers

Receptor tyrosine kinase inhibitors (TKIs) and calcium channel blockers (CCBs) are two critical categories of drugs employed in the treatment of pulmonary artery hypertension (PAH). PAH is a disease that causes high blood pressure in the pulmonary arteries, resulting in chest pain, fatigue, and shortness of breath.
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Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

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Related Experiment Video

Updated: Jun 18, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

[Osteoporosis--which therapy is confirmed?].

P M Jehle1, J Pfeilschifter

  • 1Klinik für Innere Medizin und KfH Nierenzentrum, Ev. Krankenhaus Paul Gerhardt Stift, Paul Gerhardt Strasse 42-45, 06886, Lutherstadt Wittenberg, Deutschland. p.jehle@pgdiakonie.de

Der Internist
|November 11, 2009
PubMed
Summary
This summary is machine-generated.

The updated German S3 guideline for osteoporosis emphasizes fracture prevention through muscle function, balance, and adequate calcium and vitamin D intake. It recommends specific long-term osteoporosis medications for individuals with a high 10-year risk of hip and vertebral fractures.

Related Experiment Videos

Last Updated: Jun 18, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

Area of Science:

  • Gerontology
  • Orthopedics
  • Endocrinology

Context:

  • Osteoporotic fractures significantly impact quality of life in older adults.
  • The German Association of Osteology (DVOM) has released updated S3 guidelines for osteoporosis management.
  • Effective fracture prevention is crucial for maintaining independence and health in aging populations.

Purpose:

  • To provide updated recommendations for the prophylaxis, diagnosis, and therapy of osteoporosis in adults.
  • To outline key strategies for preventing osteoporotic fractures.
  • To define criteria for initiating long-term osteoporosis medication.

Summary:

  • Key fracture prevention strategies include maintaining muscle function and balance, ensuring daily calcium intake (1000 mg) and sufficient vitamin D.
  • The guideline recommends initiating specific long-term osteoporosis medications (e.g., bisphosphonates, raloxifene) for individuals with a 30% 10-year risk of hip and vertebral fractures.
  • Prudent use of fall- and osteoporosis-associated medications is also highlighted as a critical component of prevention.

Impact:

  • Facilitates evidence-based clinical decision-making for healthcare professionals treating osteoporosis.
  • Aims to reduce the incidence of osteoporotic fractures and associated disability in the German adult population.
  • Promotes a comprehensive approach to osteoporosis management, integrating lifestyle, nutrition, and pharmacotherapy.