Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 18, 2026

White and Brown Adipose Grafts: An Approach to Correct Reproductive, Metabolic, and Renal Deficits in Black and Tan Brachyury (BTBR) Obese Mice
06:16

White and Brown Adipose Grafts: An Approach to Correct Reproductive, Metabolic, and Renal Deficits in Black and Tan Brachyury (BTBR) Obese Mice

Published on: September 9, 2025

Human IL6 enhances leptin action in mice.

M Sadagurski1, L Norquay, J Farhang

  • 1Howard Hughes Medical Institute, Division of Endocrinology, Children's Hospital Boston, Harvard Medical School, Karp Family Research Laboratories, Rm 4210, 300 Longwood Avenue, Boston, MA 02115, USA.

Diabetologia
|November 11, 2009
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Microglial ER stress response via IRE1α regulates diet-induced metabolic imbalance and obesity in mice.

Molecular metabolism·2025
Same author

Microglial NF-κB Signaling Deficiency Protects Against Metabolic Disruptions Caused by Volatile Organic Compound via Modulating the Hypothalamic Transcriptome.

bioRxiv : the preprint server for biology·2023
Same author

Acarbose protects from central and peripheral metabolic imbalance induced by benzene exposure.

Brain, behavior, and immunity·2020
Same author

IRS2 integrates insulin/IGF1 signalling with metabolism, neurodegeneration and longevity.

Diabetes, obesity & metabolism·2014
Same author

Chin augmentation: Subperiosteal and supraperiosteal implants.

Aesthetic plastic surgery·2013
Same author

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2.

Diabetologia·2012

Sustained human Interleukin-6 (IL6) in mice improved insulin sensitivity and prevented diet-induced obesity by enhancing central leptin action. This suggests IL6 plays a key role in nutrient homeostasis.

Area of Science:

  • Metabolism and Endocrinology
  • Inflammation and Immunology

Background:

  • Interleukin-6 (IL6) is an inflammatory cytokine impacting nutrient homeostasis.
  • While IL6 is linked to obesity and insulin resistance, it can also boost energy expenditure and improve glucose control.

Purpose of the Study:

  • To investigate the effects of sustained circulating human IL6 (hIL6) on nutrient homeostasis in mice.
  • To determine if hIL6 influences obesity and insulin sensitivity, particularly in the context of a high-fat diet.

Main Methods:

  • Utilized genetically modified C57BL/6J mice (hIL6(tg)) with sustained hIL6 secretion from brain and lung.
  • Assessed nutrient homeostasis, insulin sensitivity, body weight, energy expenditure, and food consumption on standard and high-fat diets.
  • Investigated the impact of leptin injections on obese mice (ob/ob and ob/ob (IL6) mice) and measured hypothalamic signaling.

More Related Videos

Body Composition and Metabolic Caging Analysis in High Fat Fed Mice
10:28

Body Composition and Metabolic Caging Analysis in High Fat Fed Mice

Published on: May 24, 2018

Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing
05:45

Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing

Published on: October 25, 2019

Related Experiment Videos

Last Updated: Jun 18, 2026

White and Brown Adipose Grafts: An Approach to Correct Reproductive, Metabolic, and Renal Deficits in Black and Tan Brachyury (BTBR) Obese Mice
06:16

White and Brown Adipose Grafts: An Approach to Correct Reproductive, Metabolic, and Renal Deficits in Black and Tan Brachyury (BTBR) Obese Mice

Published on: September 9, 2025

Body Composition and Metabolic Caging Analysis in High Fat Fed Mice
10:28

Body Composition and Metabolic Caging Analysis in High Fat Fed Mice

Published on: May 24, 2018

Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing
05:45

Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing

Published on: October 25, 2019

Main Results:

  • hIL6(tg) mice showed no systemic inflammation and enhanced insulin sensitivity compared to wild-type.
  • On a high-fat diet, hIL6(tg) mice were leaner, had lower leptin, reduced food intake, and higher energy expenditure.
  • Leptin effectively improved activity, reduced weight and food intake in ob/ob (IL6) mice, and increased hypothalamic STAT3 phosphorylation, unlike in ob/ob mice.

Conclusions:

  • Sustained human IL6 enhances central leptin action in mice.
  • This enhancement promotes improved nutrient homeostasis and protection against diet-induced obesity.
  • IL6 plays a crucial role in regulating energy balance and metabolic health via central mechanisms.