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Published on: November 10, 2010
[Identical, for better and for worse].
Irena Ulanovsky1, Polo Sujov, Zeev Weiner
1Department of Neonatology, Meyer Children's Hospital, Rambam Health Care Campus, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.
This study details identical twins with similar cerebral bilateral ventriculomegaly, a condition affecting brain fluid spaces. A potential genetic link is suggested for this rare finding in identical twins.
Area of Science:
- Neurology
- Genetics
- Obstetrics
Background:
- Ventriculomegaly, an enlargement of the brain's ventricles, can have various causes and implications.
- Identical twins often share genetic material, potentially leading to similar congenital conditions.
- Previous research has identified shared central nervous system (CNS) features in identical twins, but bilateral ventriculomegaly is not well-documented.
Purpose of the Study:
- To report the first known case of similar bilateral ventriculomegaly in monochorionic diamniotic identical twins.
- To investigate the potential for a genetic etiology of this specific neurological finding in identical twins.
- To highlight the importance of considering genetic factors in cases of concordant congenital abnormalities in identical twins.
Main Methods:
- Utilized sonography and Magnetic Resonance Imaging (MRI) for fetal assessment.
- Conducted neonatal brain Ultrasound (US) for postnatal evaluation.
- Performed clinical and imaging follow-up to monitor the condition in both twins.
Main Results:
- Both fetuses exhibited sonographic and MRI evidence of cerebral bilateral ventriculomegaly.
- Neonatal brain US confirmed similar bilateral ventriculomegaly in both infants.
- Physical and imaging similarities persisted throughout the follow-up period.
Conclusions:
- This case represents the first documented instance of similar bilateral ventriculomegaly in identical twins.
- The concordant presentation suggests a potential genetic origin for this condition in identical twins.
- Further reports of similar cases in identical twins could establish cerebral ventriculomegaly as a shared CNS feature.
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