Related Experiment Videos
[Angiomyolipomas, tuberous sclerosis and pregnancy]
Tamara Illescas Molina1, Joaquín Montalvo Montes, Esther Contreras Cecilia
1Servicio de Ginecología y Obstetricia, Hospital Clínico San Carlos, Madrid, España. tamaraillescas@hotmail.com
Ginecologia Y Obstetricia De Mexico
|November 12, 2009
Summary
Renal angiomyolipomas in pregnancy require careful consideration due to bleeding risks. Management varies, with options including embolization or surgery, balancing maternal and fetal outcomes.
Area of Science:
- Obstetrics and Gynecology
- Urology
- Radiology
Background:
- Renal angiomyolipomas (AMLs) are rare in pregnancy, posing risks of hemorrhage.
- AML characteristics and management differ based on association with conditions like tuberous sclerosis.
Observation:
- Two pregnant patients with AMLs were managed: one with bleeding (Wünderlich's syndrome) treated post-delivery, and another with tuberous sclerosis and prior embolizations had an uncomplicated pregnancy.
- Both cases resulted in successful cesarean sections.
Findings:
- Limited literature exists on managing pregnant women with bleeding AMLs (Wünderlich's syndrome).
- Treatment options include nephrectomy, embolization, or conservative management, with ongoing debate on delivery methods (vaginal vs. cesarean) to mitigate bleeding risks.
Implications:
- This highlights the importance of considering AMLs in pregnant patients with renal masses.
- Further research is needed to establish standardized therapeutic guidelines for pregnant women with AMLs, particularly those experiencing bleeding.
Related Concept Videos
mTOR Signaling and Cancer Progression
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
The Tumor Microenvironment
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Cirrhosis I: Introduction
Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Teratogenicity
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...