Related Experiment Video
Updated: Jun 18, 2026
07:02
Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
Published on: September 14, 2010
Multicentric Castleman's disease & HIV infection.
A Cotter1, J Lambert, P O'Gorman
1Department Infectious Diseases, Mater Misericordiae University Hospital, Eccles St., Dublin 7 and University College Dublin, School of Medicine & Medical Sciences, Dublin. aoife@aoifecotter.com
Irish Medical Journal
|November 12, 2009
Summary
Multicentric Castleman's Disease (MCD) is a rare condition. This case highlights MCD in an HIV-positive Nigerian patient, successfully treated with Rituximab and HAART after initial misdiagnosis.
Area of Science:
- Oncology
- Infectious Diseases
- Hematology
Background:
- Multicentric Castleman's Disease (MCD) is a rare lymphoproliferative disorder.
- Accurate diagnosis can be challenging due to non-specific symptoms.
- HIV-positive individuals are at increased risk for certain conditions.
Observation:
- A 35-year-old Nigerian patient presented with fever and splenomegaly.
- Initial diagnosis of Salmonellosis was made.
- Relapsing symptoms prompted further investigation.
Findings:
- The patient was ultimately diagnosed with Multicentric Castleman's Disease (MCD).
- Treatment with Rituximab and Highly Active Antiretroviral Therapy (HAART) led to symptom resolution.
- This case underscores the importance of considering MCD in HIV-positive patients with persistent fever and lymphadenopathy.
Implications:
- Early and accurate diagnosis of MCD is crucial for effective management.
- Rituximab and HAART offer a viable treatment option for MCD in HIV-positive patients.
- This case contributes to understanding MCD presentation and management in diverse populations.
Related Concept Videos
01:27Cryptococcal Meningitis
Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
01:27Cytomegalovirus Disease
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
01:25Immunodeficiency Diseases
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
There are three main causes of immunodeficiency disorders...
01:30Leishmaniasis
Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...
01:26Sexually Transmitted Infections
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
01:03Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...