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Semi-quantitative Assessment Using [18F]FDG Tracer in Patients with Severe Brain Injury

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Delayed and prolonged coma after acute disulfiram overdose.

S Lemoyne¹, J Raemaekers, J Daems

¹Dienst Intensieve Zorg, Sint-Augustinus, Wilrijk, Belgium.

Acta Neurologica Belgica

|November 12, 2009

Summary

Disulfiram overdose in a 35-year-old man caused prolonged coma and severe toxic encephalopathy. Symptoms included quadriparesis lasting beyond unconsciousness, highlighting disulfiram

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Area of Science:

Neuroscience
Toxicology
Pharmacology

Background:

Disulfiram is used to deter alcohol consumption.
Intentional overdose can lead to severe adverse effects.
Understanding disulfiram toxicity is crucial for clinical management.

Observation:

A 35-year-old man intentionally overdosed on disulfiram.
He experienced delayed and prolonged coma, toxic encephalopathy, and convulsions.
Quadriparesis persisted after the loss of consciousness.

Findings:

Disulfiram overdose can induce severe neurological impairment.
Symptoms include coma, seizures, and motor deficits.
The neurological effects may be prolonged and delayed.

Implications:

This case highlights the potential for severe neurotoxicity from disulfiram overdose.
Prompt recognition and management of disulfiram toxicity are essential.
Further research into the neurotoxic mechanisms of disulfiram is warranted.