Related Experiment Video
Updated: Jun 18, 2026
06:18
An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
Oral stomatitis induced by endogenous progesterone: Case report.
Eliana M Minicucci1, Aline B Carrenho, Silke A T Weber
1Department of Dermatology and Radiotherapy, Botucatu Medical School, Sao Paulo State University, UNESP, Santos, Sao Paulo, Brazil.
Summary
Recurrent oral stomatitis linked to progesterone is rare. Lesions appear monthly during the luteal phase, suggesting a hormonal cause for these mouth sores.
Area of Science:
- Endocrinology
- Dermatology
- Oral Medicine
Background:
- Oral stomatitis is inflammation of the oral mucosa.
- Hormonal influences on oral health are increasingly recognized.
- Progesterone's role in specific oral conditions remains under-investigated.
Observation:
- A 21-year-old female presented with monthly recurrent ulcerative lesions.
- Lesions were located on the buccal mucosa and upper lip.
- Onset occurred on the second day and persisted until the end of her menstrual cycle.
Findings:
- The patient's symptoms correlated with the luteal phase of her menstrual cycle.
- High endogenous progesterone levels during the luteal phase are implicated.
- This suggests a rare clinical condition of progesterone-induced oral stomatitis.
Implications:
- This case highlights a potential link between progesterone and oral ulcerative lesions.
- Further research is needed to understand the pathophysiology of hormonal stomatitis.
- Recognition of this condition can aid in diagnosis and management of similar cases.
