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Related Concept Videos

Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular spaces.
Fluid Connective Tissues: Blood and Lymph01:20

Fluid Connective Tissues: Blood and Lymph

Blood and lymph are fluid connective tissues. They contain cells, also known as formed elements, circulating in a liquid extracellular matrix, the plasma. The formed elements are derived from hematopoietic stem cells in the bone marrow. Blood and lymph connect all vital parts and carry nutrients, oxygen, and other essential molecules like antibodies.
Blood
The blood flows through blood vessels— arteries, capillaries, and veins. Blood plasma is primarily made of proteins, solutes, and water.
Inflammation01:38

Inflammation

Overview
Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Introduction to Lymphatic and Immune System01:23

Introduction to Lymphatic and Immune System

Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are born...

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Related Experiment Video

Updated: Jun 18, 2026

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice
05:59

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice

Published on: May 14, 2020

Lymphatics and inflammation.

J Wilting1, J Becker, K Buttler

  • 1Department of Anatomy and Cell Biology, Georg-August-University, Center of Anatomy, Goettingen, Germany. joerg.wilting@med.uni-goettingen.de

Current Medicinal Chemistry
|November 12, 2009
PubMed
Summary
This summary is machine-generated.

Lymphatic vessels, once overlooked, are now recognized as key regulators in inflammation. Research shows these vessels actively participate in initiating and resolving inflammatory responses, offering new therapeutic avenues.

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Last Updated: Jun 18, 2026

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice
05:59

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice

Published on: May 14, 2020

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Digestion of the Murine Liver for a Flow Cytometric Analysis of Lymphatic Endothelial Cells
08:07

Digestion of the Murine Liver for a Flow Cytometric Analysis of Lymphatic Endothelial Cells

Published on: January 7, 2019

Area of Science:

  • Immunology
  • Vascular Biology
  • Cell Biology

Background:

  • Inflammation is a critical tissue response involving blood vessels, but lymphatic vessels have been historically neglected in research.
  • Recent identification of lymphatic endothelial cell (LEC)-specific molecules enables detailed study of lymphatic vessel function.
  • Emerging evidence suggests lymphatics play a direct role in modulating inflammatory processes.

Purpose of the Study:

  • To review the fundamental aspects of inflammation and lymphatic vessel structure.
  • To explore the involvement of lymphatics in human inflammation-associated diseases.
  • To summarize current knowledge on animal models and molecular mechanisms linking lymphatics and inflammation.

Main Methods:

  • Literature review integrating basic inflammation principles, lymphatic biology, and disease associations.
  • Analysis of studies utilizing novel LEC-specific markers for tissue and cellular investigation.
  • Examination of animal models to elucidate lymphatic-inflammation interactions.

Main Results:

  • Lymphatic vessels are not merely passive conduits but actively influence inflammation induction and resolution.
  • Identification of LEC-specific molecules has revolutionized the study of lymphatic vessel function.
  • Clinical potential exists for targeting lymphatics in managing inflammation-associated diseases.

Conclusions:

  • Lymphatic vessels are integral components of the inflammatory response, impacting both its initiation and resolution.
  • The study of lymphatics in inflammation represents a burgeoning field with significant clinical implications.
  • Further research into lymphatic endothelial cells and their molecular interactions promises novel therapeutic strategies.