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Routine Screening Method for Microparticles in Platelet Transfusions
Published on: January 31, 2018
ABO-identical versus nonidentical platelet transfusion: a systematic review
Nadine Shehata1, Alan Tinmouth, Gary Naglie
1Department of Medicine, University of Toronto, Division of Hematology, St Michael's Hospital, Toronto, Ontario, Canada. shehatan@smh.toronto.on.ca
Transfusion
|November 12, 2009
Summary
ABO-identical platelet (PLT) transfusions show a higher PLT count increment. However, more randomized controlled trials are needed to confirm benefits in survival, bleeding, or transfusion reactions for hematologic/oncologic patients.
Area of Science:
- Hematology
- Transfusion Medicine
- Oncology
Background:
- The clinical significance of ABO matching for platelet (PLT) transfusions remains unclear.
- Current evidence is insufficient to define the benefits of ABO-identical PLT transfusion.
Purpose of the Study:
- To assess if ABO-identical PLT transfusion improves mortality and/or morbidity in patients with hematologic/oncologic disorders.
- To review existing literature on ABO matching in PLT transfusions.
Main Methods:
- Systematic review of studies published up to January 2009.
- Inclusion of data on mortality, morbidity, PLT refractoriness, and PLT increment.
- Analysis of 19 studies, including 3 randomized controlled trials and 16 observational studies, totaling 1502 patients.
Main Results:
- ABO-identical PLT transfusion consistently resulted in a higher PLT count increment.
- No consistent benefits were observed in clinical outcomes such as survival, bleeding events, or transfusion reactions.
- Conflicting results were reported regarding survival and the impact on PLT and red blood cell utilization.
Conclusions:
- ABO-identical PLT transfusion leads to a greater increase in platelet count.
- Further randomized controlled trials are essential to definitively establish the impact of ABO-identical PLT transfusion on patient survival, bleeding, and transfusion reactions.
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