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Related Experiment Video

Updated: Jun 18, 2026

Fabrication Procedures and Birefringence Measurements for Designing Magnetically Responsive Lanthanide Ion Chelating Phospholipid Assemblies
09:38

Fabrication Procedures and Birefringence Measurements for Designing Magnetically Responsive Lanthanide Ion Chelating Phospholipid Assemblies

Published on: January 3, 2018

Chapter 10 - Lanthanide-loaded paramagnetic liposomes as switchable magnetically oriented nanovesicles.

Silvio Aime1, Daniela Delli Castelli, Enzo Terreno

  • 1Department of Chemistry IFM and Molecular Imaging Center, University of Torino, Torino, Italy.

Methods in Enzymology
|November 12, 2009
PubMed
Summary
This summary is machine-generated.

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Researchers created magnetically orientable liposomes by applying osmotic stress to lanthanide-loaded vesicles. These nanoparticles align in magnetic fields, with orientation detectable via water proton shifts, showing potential for in vivo medical imaging applications.

Area of Science:

  • Nanotechnology
  • Biophysics
  • Materials Science

Background:

  • Liposomes are versatile nanoscale vesicles used in drug delivery and imaging.
  • Controlling liposome orientation is crucial for targeted applications.
  • Paramagnetic lanthanide complexes offer magnetic properties exploitable for orientation.

Purpose of the Study:

  • To develop a method for preparing magnetically orientable liposomes.
  • To investigate the relationship between liposome membrane magnetic properties and orientation.
  • To explore the potential of magnetically oriented liposomes in medical imaging.

Main Methods:

  • Preparation of unilamellar liposomes loaded with paramagnetic lanthanide(III) complexes.
  • Application of hyperosmotic stress to induce nonspherical vesicle formation.

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Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins
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Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Published on: August 31, 2019

Related Experiment Videos

Last Updated: Jun 18, 2026

Fabrication Procedures and Birefringence Measurements for Designing Magnetically Responsive Lanthanide Ion Chelating Phospholipid Assemblies
09:38

Fabrication Procedures and Birefringence Measurements for Designing Magnetically Responsive Lanthanide Ion Chelating Phospholipid Assemblies

Published on: January 3, 2018

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins
11:30

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Published on: August 31, 2019

  • Orientation in a static magnetic field and characterization via (1)H NMR spectroscopy to measure magnetic susceptibility anisotropy (ΔχLIPO).

    • Main Results:

    • Nonspherical, lens-shaped liposomes were successfully prepared and showed magnetic orientation.
    • Liposome orientation (parallel or perpendicular to the field) was determined by the sign of ΔχLIPO, influenced by the incorporated lanthanide complex.
    • The magnetic orientation was maintained in vivo, confirmed by NMR spectroscopy.

    Conclusions:

    • Magnetically orientable nonspherical liposomes can be controllably prepared using osmotic stress and paramagnetic complexes.
    • The orientation mechanism is directly linked to the magnetic susceptibility anisotropy of the liposome membrane.
    • These findings present promising avenues for using magnetically oriented liposomes in advanced medical imaging techniques.