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Related Experiment Videos

Rheumatoid arthritis. New developments in treatment.

L C Corman1

  • 1Department of Medicine, J. Hillis Miller Health Center, University of Florida College of Medicine, Gainesville 32610.

Postgraduate Medicine
|February 1, 1991
PubMed
Summary

For active rheumatoid arthritis, disease-modifying antirheumatic drugs (DMARDs) are recommended if NSAIDs fail. Hydroxychloroquine is a common, well-tolerated DMARD, but requires careful monitoring for potential severe toxic effects.

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Area of Science:

  • Rheumatology
  • Pharmacology

Background:

  • Active rheumatoid arthritis (RA) often requires treatment beyond nonsteroidal anti-inflammatory drugs (NSAIDs).
  • Disease-modifying antirheumatic drugs (DMARDs) are crucial for managing RA progression.
  • Treatment selection involves considering efficacy and tolerability.

Purpose of the Study:

  • To review the role of DMARDs in rheumatoid arthritis management.
  • To highlight hydroxychloroquine as a commonly used and well-tolerated DMARD.
  • To emphasize the importance of monitoring for adverse effects of DMARDs.

Main Methods:

  • Literature review on rheumatoid arthritis treatment guidelines.
  • Analysis of current practices in DMARD selection and monitoring.
  • Focus on hydroxychloroquine (Plaquenil) sulfate's clinical profile.

Main Results:

  • Prompt initiation of DMARDs is advised when NSAIDs provide insufficient relief for active RA.
  • Hydroxychloroquine is a widely utilized and generally well-tolerated DMARD.
  • Alternative DMARDs may be trialed if initial therapy is ineffective.

Conclusions:

  • DMARDs are essential for patients with active RA unresponsive to NSAIDs.
  • Hydroxychloroquine represents a significant option in RA pharmacotherapy.
  • Vigilant patient follow-up is critical due to the potential for severe and unpredictable toxic effects associated with DMARDs.

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