Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

[Atypical giant cell arteritis].

H Marty¹, C Bachmeier

¹Medizinische Abteilung des Bezirksspitals Obersimmental, Zweisimmen.

Schweizerische Medizinische Wochenschrift

|January 9, 1991

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Inhibition of ADAM10 promotes the clearance of Aβ across the BBB by reducing LRP1 ectodomain shedding.

Fluids and barriers of the CNS·2016

Same author

[Assessment of possible drug-drug interactions in psychopharmacotherapy after hospital discharge using an interactive database].

Fortschritte der Neurologie-Psychiatrie·2010

Same author

Alcohol intoxication at a university hospital acute medicine unit--with special consideration of young adults: an 8-year observational study from Switzerland.

Emergency medicine journal : EMJ·2010

Same author

Discriminatory ability of quantitative ultrasound parameters and bone mineral density in a population-based sample of postmenopausal women with vertebral fractures: results of the Basel Osteoporosis Study.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2002

Same author

[Polymorphic ventricular tachycardia after intravenous adenosine].

Schweizerische medizinische Wochenschrift·2000

Same author

[Salmonella, heart and pancreas].

Schweizerische medizinische Wochenschrift·1999

Same journal

Respiratory function test in the case of temporary phrenic nerve contusion, associated with pneumoperitoneum; About the diagnostic value of laparoscopy.

Schweizerische medizinische Wochenschrift·2010

Same journal

Treatment of pulmonary tuberculosis and pleurisy by means of temporary paralysis of the diaphragm, supported by the pneumoperitoneum.

Schweizerische medizinische Wochenschrift·2010

Same journal

Boeck's disease as a tuberculous syndrome.

Schweizerische medizinische Wochenschrift·2010

Same journal

Enteral primary tubercular complexes

Schweizerische medizinische Wochenschrift·2010

Same journal

Tuberculous stenoses of the large bronchi.

Schweizerische medizinische Wochenschrift·2010

Same journal

About the enzyme action.

Schweizerische medizinische Wochenschrift·2010

See all related articles

Giant-cell arteritis in the elderly can present atypically with severe systemic symptoms. Early steroid treatment significantly improved outcomes in two elderly patients with this condition.

Area of Science:

Rheumatology
Vascular Medicine
Geriatrics

Background:

Giant-cell arteritis (GCA) is a systemic vasculitis primarily affecting large and medium-sized arteries.
While typically presenting with headache and jaw claudication, GCA can exhibit diverse and severe manifestations, particularly in elderly individuals.
Atypical presentations in the elderly may mimic other systemic diseases, posing diagnostic challenges.

Observation:

Two elderly patients (78-year-old female, 72-year-old male) presented with histologically confirmed giant-cell arteritis.
The female patient experienced fever, weight loss, arrhythmias (atrial fibrillation, atrial flutter), and axillary artery occlusion, suggesting coronary and peripheral vascular involvement.
The male patient exhibited similar constitutional symptoms along with neurological deficits (amaurosis, mononeuritis multiplex, polyneuropathy, myopathy) and subarachnoid hemorrhage, complicated by intestinal perforation.

Related Experiment Videos

Findings:

The clinical course in these elderly patients was characterized by severe systemic and organ-specific manifestations beyond typical GCA symptoms.
Inflammatory vascular processes led to significant cardiovascular and neurological complications, including arterial occlusion and hemorrhage.
Both patients demonstrated a substantial positive response to corticosteroid therapy.

Implications:

This case series highlights the importance of considering atypical presentations of giant-cell arteritis in the elderly, even with non-specific symptoms.
Prompt diagnosis and initiation of immunosuppressive therapy, such as corticosteroids, are crucial for managing severe GCA and preventing irreversible complications.
Recognizing the broad spectrum of GCA manifestations is essential for timely intervention and improved patient outcomes in geriatric populations.