Related Experiment Video
Updated: Jun 18, 2026

Live-cell Imaging of Endocytic Transport using Functionalized Nanobodies in Cultured Cells
Published on: October 17, 2025
Integrins: masters and slaves of endocytic transport
Patrick T Caswell1, Suryakiran Vadrevu, Jim C Norman
1Beatson Institute for Cancer Research, Cancer Research UK, Glasgow, G61 3BX, Scotland.
Abstract:
Since it has become clear that adhesion receptors are trafficked through the endosomal pathway and that this can influence their function, much effort has been invested in obtaining detailed descriptions of the molecular machinery responsible for internalizing and recycling integrins. New findings indicate that integrin trafficking dictates the nature of Rho GTPase signalling during cytokinesis and cell migration. Furthermore, integrins can exert control over the trafficking of other receptors in a way that drives cancer cell invasion and tumour angiogenesis.
Related Concept Videos
The Early Endosome: Endocytosis of Transferrin
Introduction to Membrane Traffic
The transport of soluble and membrane proteins is mediated by transport vesicles that collect cargo from one cellular compartment and deliver it to another by fusing with the target organelle membrane. The Rab...
Protein Translocation Machinery on the ER Membrane
Sec61 protein conducting channel
In eukaryotes, the translocon complex comprises a core heterotrimeric translocator channel called the Sec61 complex. This channel includes three transmembrane proteins, Sec61α, Sec61β, and Sec61γ, and is the largest subunit of the translocon complex.
Intralumenal Vesicles and Multivesicular Bodies
Clathrin Coated Vesicles
Protein Transport into the Inner Mitochondrial Membrane
Transport of mitochondrial precursors across the TIM23 channel is driven by...

