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Potentiometry: Membrane Electrodes

Membrane electrodes, also known as p-ion electrodes, use membranes that selectively interact with free analyte ions, generating a potential difference across the membrane. The resulting membrane potential, known as the asymmetry potential, is not zero even when analyte concentrations on both sides of the membrane are equal. The membrane's response is typically not selective to a single analyte but proportional to the concentration of all ions in the sample solution capable of interacting at the...
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Related Experiment Video

Updated: Jun 18, 2026

Electric Cell-substrate Impedance Sensing for the Quantification of Endothelial Proliferation, Barrier Function, and Motility
12:30

Electric Cell-substrate Impedance Sensing for the Quantification of Endothelial Proliferation, Barrier Function, and Motility

Published on: March 28, 2014

Single cell electric impedance topography: mapping membrane capacitance.

Sameera Dharia1, Harold E Ayliffe, Richard D Rabbitt

  • 1Department of Bioengineering, University of Utah, 72 South Central Campus Dr., Salt Lake City, UT 84112, USA.

Lab on a Chip
|November 12, 2009
PubMed
Summary
This summary is machine-generated.

Single-cell electric impedance topography (sceTopo) maps cell membrane capacitance distribution. This new technique reveals differences between cell regions and estimates cell shape for biological studies.

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Fabrication and Validation of an Organ-on-chip System with Integrated Electrodes to Directly Quantify Transendothelial Electrical Resistance
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Fabrication and Validation of an Organ-on-chip System with Integrated Electrodes to Directly Quantify Transendothelial Electrical Resistance

Published on: September 26, 2017

Related Experiment Videos

Last Updated: Jun 18, 2026

Electric Cell-substrate Impedance Sensing for the Quantification of Endothelial Proliferation, Barrier Function, and Motility
12:30

Electric Cell-substrate Impedance Sensing for the Quantification of Endothelial Proliferation, Barrier Function, and Motility

Published on: March 28, 2014

Fabrication and Validation of an Organ-on-chip System with Integrated Electrodes to Directly Quantify Transendothelial Electrical Resistance
10:51

Fabrication and Validation of an Organ-on-chip System with Integrated Electrodes to Directly Quantify Transendothelial Electrical Resistance

Published on: September 26, 2017

Area of Science:

  • Biophysics
  • Cell Biology
  • Electrical Engineering

Background:

  • Cell membrane capacitance is crucial for cellular functions.
  • Mapping capacitance distribution at the single-cell level is challenging.
  • Existing techniques lack spatial resolution for membrane properties.

Purpose of the Study:

  • Introduce single-cell electric impedance topography (sceTopo) for mapping membrane capacitance.
  • Characterize spatial capacitance variations in living cells.
  • Assess the utility of sceTopo for determining cell shape and extracellular environment.

Main Methods:

  • Developed sceTopo using a circular chamber with eight peripheral electrodes.
  • Measured electric impedance (10 kHz-5 MHz) between adjacent electrodes.
  • Applied sceTopo to Xenopus oocytes, utilizing their distinct hemispheres for validation.

Main Results:

  • Generated topographical maps of membrane capacitance distribution.
  • Observed significant differences in impedance imaginary component between Xenopus oocyte hemispheres.
  • Successfully mapped extracellular electrical shunt paths to estimate cell location and shape.

Conclusions:

  • sceTopo provides high-resolution spatial mapping of single-cell membrane capacitance.
  • The technique is sensitive to variations in membrane properties within a cell.
  • sceTopo offers a novel method for characterizing cell morphology and extracellular interactions.