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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

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Related Experiment Video

Updated: Jun 18, 2026

Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

Targeted therapies in thyroid cancer.

Jaume Capdevila1, Jose Perez-Garcia, Gabriel Obiols

  • 1Medical Oncology Department, Vall d'Hebron University Hospital, P. Vall d'Hebron 119-129, 08035, Barcelona, Spain.

Targeted Oncology
|November 12, 2009
PubMed
Summary

Differentiated thyroid carcinoma, a common endocrine cancer, has limited treatment options for radioiodine-resistant metastatic disease. Novel targeted therapies show promise for these patients.

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Area of Science:

  • Endocrinology
  • Oncology
  • Molecular Biology

Background:

  • Differentiated thyroid carcinoma is the most common endocrine neoplasm.
  • While generally having an excellent prognosis, metastatic and radioiodine-resistant cases lack effective therapeutic options.
  • Understanding molecular aberrations driving tumor growth is key to developing new treatments.

Purpose of the Study:

  • To explore novel therapeutic targets for differentiated thyroid carcinoma.
  • To investigate the role of molecular pathways and angiogenesis in tumor progression.
  • To highlight the potential of new targeted therapies for resistant thyroid cancer.

Main Methods:

  • Review of current literature on differentiated thyroid carcinoma.
  • Analysis of molecular aberrations, including the RET/PTC-RAS-RAF-MAPK pathway.
  • Examination of the role of vascular aberrations and angiogenesis in tumor growth.

Main Results:

  • The RET/PTC-RAS-RAF-MAPK pathway is implicated in differentiated thyroid carcinoma carcinogenesis.
  • Vascular aberrations and angiogenesis are associated with tumor growth.
  • Emerging targeted therapies show encouraging initial results.

Conclusions:

  • Targeted therapies offer a new avenue for treating patients with advanced, radioiodine-resistant differentiated thyroid carcinoma.
  • Further research into molecular targets and angiogenesis is crucial.
  • These advancements provide hope for patients with limited treatment options.