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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
Published on: September 20, 2018
Childhood Kikuchi-Fujimoto disease
Chao Chun Zou1, Zheng Yan Zhao, Li Liang
1Department of Medicine, The Children's Hospital of Zhejiang University School of Medicine, Hangzhou, China. zou108cc@yahoo.com
Indian Journal of Pediatrics
|November 12, 2009
Summary
Kikuchi-Fujimoto disease (KFD) in children often presents with fever and lymphadenopathy. Viral infections, particularly Epstein-Barr virus (EBV), may trigger a hyperimmune response contributing to KFD.
Area of Science:
- Pediatrics
- Immunology
- Infectious Diseases
Background:
- Kikuchi-Fujimoto disease (KFD) is a rare, self-limiting disorder characterized by lymphadenopathy.
- Understanding KFD's clinical spectrum and potential triggers in pediatric populations is crucial for timely diagnosis.
Purpose of the Study:
- To investigate the clinical features of Kikuchi-Fujimoto disease (KFD) in Chinese children.
- To explore the potential relationship between viral infections and the pathogenesis of KFD in this demographic.
Main Methods:
- Retrospective review of 36 Chinese children diagnosed with KFD.
- Analysis of clinical data, including age, gender, symptoms, laboratory findings, and viral antigen detection (EBV, HSV-2).
Main Results:
- The study included 36 children (mean age 10.1 years; male:female ratio 1.8:1).
- Common symptoms were fever (23/36) and generalized lymphadenopathy (36/36).
- Epstein-Barr virus (EBV) was detected in 24/29 cases (IgG), suggesting a potential role in KFD pathogenesis.
Conclusions:
- Children presenting with fever and lymphadenopathy may have KFD, warranting early lymph node biopsy.
- A hyperimmune response to viruses like EBV and HSV-2 may contribute to the development of KFD in children.
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