Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Esophageal Perforation-I: Introduction

Esophageal Perforation-I: Introduction

Esophageal perforation is a severe medical condition characterized by a breach in the integrity of the esophageal wall. This breach can occur due to various factors such as trauma, medical procedures, or underlying diseases. When the esophageal wall is compromised, it allows food, fluids, and digestive juices into the chest cavity or adjacent structures, leading to potential complications and health risks.
The location of esophageal perforation can vary, occurring anywhere along the esophagus.

Epistaxis

Epistaxis

Epistaxis, or nosebleeds, occurs when small, swollen blood vessels in the nasal mucous membrane rupture. Typically, the anterior septum is the primary site of occurrence.
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...

Esophageal Perforation-II: Clinical Manifestations and Management

Esophageal Perforation-II: Clinical Manifestations and Management

Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:

Aneurysm III: Interprofessional Care

Aneurysm III: Interprofessional Care

Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...

Prevention of Further Absorption of Poison

Prevention of Further Absorption of Poison

In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...

Pneumothorax-II

Pneumothorax-II

Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Sarcopenia Predicts Mortality and Hepatic Encephalopathy After TIPS in Older Adults With Cirrhosis and Improves Prognostic Scores.

Liver international : official journal of the International Association for the Study of the Liver·2026

Same author

Immune Checkpoint Inhibitors in Hepatocellular Carcinoma Before and After Liver Transplantation: A Systematic Review.

Cancers·2026

Same author

Intrinsic Tumor Aggressiveness Dictates Hypoxia-Driven Metabolic Programs in Hepatocellular Carcinoma.

International journal of molecular sciences·2026

Same author

Prevention of Portal Hypertension Complications Beyond Primary TIPS Indication Is Independent of Endoprosthesis Under-Dilation.

Liver international : official journal of the International Association for the Study of the Liver·2026

Same author

Predicting the Risk of Decompensation in Patients With Cirrhosis: A Validated Machine Learning Approach.

The American journal of gastroenterology·2026

Same author

The qEEG-TIPS score: Development of a predictive model for recurrent overt hepatic encephalopathy after elective TIPS.

JHEP reports : innovation in hepatology·2026

Search research articles

Related Experiment Video

Updated: Jun 18, 2026

Open Tracheostomy Gastric Acid Aspiration Murine Model of Acute Lung Injury Results in Maximal Acute Nonlethal Lung Injury

Open Tracheostomy Gastric Acid Aspiration Murine Model of Acute Lung Injury Results in Maximal Acute Nonlethal Lung Injury

Published on: February 26, 2017

Massive GI bleeding due to accidental ASA inhalation.

Marcello Bianchini¹, Maurizio Cavina, Valentina Boarino

¹Gastroenterology and Hepatology Unit, Policlinico di Modena, Modena, Italy.

|November 13, 2009

Summary

A farmer with idiopathic thrombocytopenia experienced massive rectal bleeding after inhaling acetylsalicylic acid. Small bowel erosions were found, and platelet function normalized with conservative treatment, resolving the hemorrhage.

More Related Videos

A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation

A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation

Published on: August 30, 2019

Related Experiment Videos

Last Updated: Jun 18, 2026

Open Tracheostomy Gastric Acid Aspiration Murine Model of Acute Lung Injury Results in Maximal Acute Nonlethal Lung Injury

Open Tracheostomy Gastric Acid Aspiration Murine Model of Acute Lung Injury Results in Maximal Acute Nonlethal Lung Injury

Published on: February 26, 2017

A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation

A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation

Published on: August 30, 2019

Area of Science:

Gastroenterology
Hematology
Toxicology

Background:

Idiopathic thrombocytopenia (ITP) is an autoimmune disorder characterized by low platelet counts.
Patients with ITP are at increased risk of bleeding, particularly severe hemorrhage.
Gastrointestinal bleeding can be a serious complication of ITP.

Observation:

A 38-year-old male farmer with known ITP presented with massive rectal bleeding and syncope.
Endoscopic evaluations were negative for upper or lower gastrointestinal lesions.
Capsule endoscopy revealed diffuse petechial hemorrhage and erosions in the small intestine.

Findings:

Thromboelastography indicated significantly reduced platelet aggregation upon admission, which normalized within two days.
The patient's bleeding episode was temporally linked to the inhalation of a large quantity of acetylsalicylic acid.
Conservative management led to complete recovery without recurrence of bleeding, despite persistent thrombocytopenia.

Implications:

This case highlights a potential iatrogenic cause of severe gastrointestinal bleeding in patients with pre-existing thrombocytopenia.
Occupational exposure to high doses of acetylsalicylic acid can precipitate significant bleeding events.
Prompt diagnosis and conservative management can be effective in resolving such hemorrhages.