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A report from the UNOS Scientific Renal Transplant Registry
P I Terasaki1, J M Cecka, Y Cho
1UCLA Tissue Typing Laboratory 90024.
Transplantation Proceedings
|February 1, 1991
Summary
The UNOS Kidney Transplant Registry is operational, enabling analysis of kidney transplant factors. Key findings highlight histocompatibility and HLA matching as crucial for cadaveric kidney recipients.
Area of Science:
- Nephrology
- Transplantation Immunology
- Biostatistics
Background:
- The United Network for Organ Sharing (UNOS) Kidney Transplant Registry is now fully operational.
- Data analysis capabilities are expanding beyond UCLA to include investigators initiating projects through UNOS central and from HICFA and USRDS.
- Future analyses will benefit from a large accumulated case volume.
Purpose of the Study:
- To report the operational status of the UNOS Kidney Transplant Registry.
- To outline anticipated data analyses from multiple sources.
- To identify current major factors influencing kidney transplant outcomes.
Main Methods:
- Utilizing data from the UNOS Kidney Transplant Registry.
- Analyzing factors related to donor type (living related vs. cadaveric).
- Assessing the impact of Human Leukocyte Antigen (HLA) mismatching.
Main Results:
- Histocompatibility differences between living related and cadaveric donors are significant factors.
- Degrees of HLA mismatching in recipients of cadaveric kidneys are major determinants of success.
- Immunization due to prior transplant rejection is the second most important factor.
Conclusions:
- The UNOS Kidney Transplant Registry provides a robust platform for future kidney transplant research.
- Histocompatibility and HLA matching are critical considerations for cadaveric kidney transplantation.
- Understanding factors like donor type and prior rejection is essential for improving transplant outcomes.