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Published on: December 29, 2021
Independent sets of DNA oligonucleotides for nanotechnology applications
Weixia Yu1, Ju Seok Lee, Cole Johnson
1Department of Computer Science and Computer Engineering, University of Arkansas, Fayetteville, AR 72701, USA. wxyu@ucla.edu
Abstract:
Independent sets of DNA oligonucleotides, which only bind with their Watson-Crick complements, have potential use in self-assembly of nanostructures, since they minimize errors and inefficiency from unwanted binding. A software tool implemented a thermodynamic model for DNA duplex formation and was used to generate large independent sets of DNA oligonucleotides. The principle of the approach was experimentally verified on a sample set of oligonucleotides.
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