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VIGS-Mediated Forward Genetics Screening for Identification of Genes Involved in Nonhost Resistance
Published on: August 23, 2013
PRGdb: a bioinformatics platform for plant resistance gene analysis
Walter Sanseverino1, Guglielmo Roma, Marco De Simone
1Department of Soil, Plant, Environmental and Animal Production Sciences, University of Naples 'Federico II', Via Università 100, 80055 Portici, Italy.
Nucleic Acids Research
|November 13, 2009
Summary
PRGdb is the first comprehensive database for plant resistance genes (R-genes), cataloging over 16,000 genes across 192 species. It aids research by linking genomic and phenotypic data for plant disease resistance studies.
Area of Science:
- Plant genomics and bioinformatics
- Plant pathology and disease resistance
Background:
- Plant resistance genes (R-genes) are crucial for defending against pathogens.
- A centralized, comprehensive resource for plant R-genes was lacking.
Purpose of the Study:
- To develop the first comprehensive, web-accessible database of plant resistance genes (PRGdb).
- To provide a user-friendly platform for exploring R-gene information and facilitating research.
Main Methods:
- Compilation of manually curated, NCBI-sourced, and computationally predicted R-genes.
- Development of the Disease Resistance Analysis and Gene Orthology (DRAGO) pipeline for R-gene prediction.
- Integration of genomic and phenotypic data for R-genes.
Main Results:
- PRGdb contains over 16,000 known and putative R-genes from 192 plant species and 115 pathogens.
- Discovery and characterization of novel R-gene classes with unknown domain combinations.
- A user-friendly interface with query tools for data exploration.
Conclusions:
- PRGdb serves as a foundational resource for plant disease resistance research.
- The database facilitates the study of R-gene functions and the development of new crop protection strategies.
- PRGdb's structure allows for future integration and expansion.
