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Updated: Jun 18, 2026
08:03
Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
Published on: December 7, 2021
MicrobesOnline: an integrated portal for comparative and functional genomics
Paramvir S Dehal1, Marcin P Joachimiak, Morgan N Price
1Virtual Institute for Microbial Stress and Survival, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. psdehal@lbl.gov
Nucleic Acids Research
|November 13, 2009
Summary
MicrobesOnline offers a comprehensive resource for microbial genomics, featuring over 1000 genomes and expression data. Future updates will include comparative metagenomic analysis for enhanced microbial genome exploration.
Area of Science:
- Microbial Genomics
- Bioinformatics
- Comparative Genomics
Background:
- MicrobesOnline has served as a community resource for comparative and functional genome analysis since 2003.
- The portal hosts over 1000 complete microbial genomes (bacteria, archaea, fungi) and thousands of expression microarrays.
Purpose of the Study:
- To provide a centralized platform for analyzing microbial genome data.
- To facilitate gene annotation, evolutionary history reconstruction, and identification of co-regulated genes.
- To offer tools for phylogenetic analysis, metabolic pathway comparison, and sequence analysis.
Main Methods:
- Comparative genome browsing based on phylogenetic trees.
- Gene searching by expression profile.
- Identification and conservation analysis of regulatory motifs.
- Phylogenetic profile searches and comparative pathway views.
Main Results:
- The platform integrates diverse microbial genomic data, including genomes and expression data.
- Tools are available for phylogenetic analysis, gene co-regulation identification, and metabolic pathway comparison.
- The resource supports sequence analysis and integrates with other microbial genome databases.
Conclusions:
- MicrobesOnline is a valuable resource for researchers in microbial genomics and bioinformatics.
- The platform facilitates comparative genome analysis and functional genomics studies.
- Upcoming updates will enhance capabilities with metagenomic data analysis.
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