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Effects of pitavastatin (LIVALO Tablet) on high density lipoprotein cholesterol (HDL-C) in hypercholesterolemia

Tamio Teramoto1, Hitoshi Shimano, Koutaro Yokote

  • 1Department of Internal Medicine, Teikyo University School of Medicine, Japan. ttera@med.teikyo-u.ac.jp

Journal of Atherosclerosis and Thrombosis
|November 13, 2009
PubMed

Insights

Pitavastatin effectively lowers LDL-C and triglycerides while significantly increasing HDL-C, especially in patients with low HDL-C levels. This study confirms its sustained efficacy over 104 weeks.

Area of Science:

  • Cardiology
  • Pharmacology
  • Clinical Lipidology

Background:

  • Low high-density lipoprotein cholesterol (HDL-C) is a significant risk factor for cardiovascular disease (CVD).
  • Statins are known for their efficacy in lowering LDL-C and raising HDL-C.

Purpose of the Study:

  • To evaluate the long-term effects of pitavastatin on plasma lipids, with a specific focus on HDL-C.
  • To analyze pitavastatin's impact on HDL-C levels in hypercholesterolemic patients, particularly those with initially low HDL-C.

Main Methods:

  • Utilized the LIVALO effectiveness and safety (LIVES) Study database, a prospective, post-marketing surveillance study.
  • Included 20,279 hypercholesterolemic patients treated with pitavastatin for 104 weeks.
  • Analyzed changes in total cholesterol (TC), LDL-C, triglycerides (TG), and HDL-C, including subgroup analysis for low HDL-C levels.

Main Results:

  • Significant reductions in TC (-21.0%) and LDL-C (-31.3%) were observed.
  • HDL-C increased by 5.9% overall and by 24.6% in patients with baseline low HDL-C (<40 mg/dL).
  • Sustained elevation of HDL-C was noted in the low HDL-C group throughout the 104-week study period, with enhanced increases observed after switching from other statins.

Conclusions:

  • Pitavastatin demonstrated stable efficacy in managing LDL-C, TG, and HDL-C levels over 104 weeks.
  • The drug continuously increased HDL-C, particularly in patients with initially low HDL-C levels.
  • Factors such as BMI, diabetes, liver disease, and prior cholesterol-lowering treatments influenced HDL-C response.
Abstract

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